Upregulation of microglial C1q expression has no effects on nigrostriatal dopaminergic injury in the MPTP mouse model of Parkinson disease.

@article{Depboylu2011UpregulationOM,
  title={Upregulation of microglial C1q expression has no effects on nigrostriatal dopaminergic injury in the MPTP mouse model of Parkinson disease.},
  author={Candan Depboylu and Kathrin Schorlemmer and Martin Klietz and Wolfgang Hermann Oertel and Eberhard Weihe and G{\"u}nter U. H{\"o}glinger and Martin K-H Schaefer},
  journal={Journal of neuroimmunology},
  year={2011},
  volume={236 1-2},
  pages={39-46}
}
Here we analyzed C1q, the initial recognition subcomponent of classical complement activation cascade, in an experimental model of Parkinson disease (PD). Nigrostriatal dopaminergic pathway injury was induced by treatment of wildtype mice subchronically with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Constitutive expression of C1q was restricted… CONTINUE READING