Upregulation of microglia in drug users with and without pre-symptomatic HIV infection.

@article{Tomlinson1999UpregulationOM,
  title={Upregulation of microglia in drug users with and without pre-symptomatic HIV infection.},
  author={Gary Tomlinson and Peter Simmonds and Anthony Busuttil and Andrew J. Chiswick and Jeanne Elisabeth Bell},
  journal={Neuropathology and applied neurobiology},
  year={1999},
  volume={25 5},
  pages={
          369-79
        }
}
It is generally thought that infection of the central nervous system (CNS) by HIV-1 can occur early, even around the time of seroconversion, and evidence from animal studies supports this. However, the mode and timing of viral entry remain poorly understood since there have been comparatively few studies of the early neuropathology of HIV infection. In this study, samples of frontal and temporal lobes, and basal ganglia, were selected from 12 HIV-positive drug users who had been infected for 4… CONTINUE READING

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