Upregulation of miR-194 contributes to tumor growth and progression in pancreatic ductal adenocarcinoma.

@article{Zhang2014UpregulationOM,
  title={Upregulation of miR-194 contributes to tumor growth and progression in pancreatic ductal adenocarcinoma.},
  author={Jing Zhang and Chen-yan Zhao and Shu-Hui Zhang and Dang-hui Yu and Ying Chen and Qing-Hua Liu and Min Shi and Can-rong Ni and Ming-hua Zhu},
  journal={Oncology reports},
  year={2014},
  volume={31 3},
  pages={
          1157-64
        }
}
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of human cancer worldwide. In the present study, we investigated the diagnostic and biological significance of microRNA-194 (miR-194) in PDAC. miRNA expression profiling of human PDACs and adjacent normal pancreatic tissues identified a total of 16 genes including miR-194 with >1.15-fold expression changes (8 overexpressed and 8 underexpressed). Quantitative real-time polymerase chain reaction (PCR) revealed elevation of… 
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High serum miR-373-3p before the start and low serumMiR-194-5p after one cycle are associated with early tumor progression during FOLFIRINOX, a multivariable model including disease stage and baseline CA19-9 level.
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