Upregulation of major histocompatibility complex class I on liver cells by hepatitis C virus core protein via p53 and TAP1 impairs natural killer cell cytotoxicity.

@article{Herzer2003UpregulationOM,
  title={Upregulation of major histocompatibility complex class I on liver cells by hepatitis C virus core protein via p53 and TAP1 impairs natural killer cell cytotoxicity.},
  author={Kerstin Herzer and Christine S. Falk and Jens Encke and S{\"o}ren T. Eichhorst and Axel Ulsenheimer and Barbara Seliger and Peter Heinrich Krammer},
  journal={Journal of virology},
  year={2003},
  volume={77 15},
  pages={8299-309}
}
The mechanisms of immune evasion and the role of the early immune response in chronic infection caused by hepatitis C virus (HCV) are still unclear. Here, we present evidence for a cascade of molecular events that the virus initiates to subvert the innate immune attack. The HCV core protein induced p53-dependent gene expression of TAP1 (transporter associated with antigen processing 1) and consecutive major histocompatibility complex (MHC) class I upregulation. Moreover, in p53-deficient liver… CONTINUE READING
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Recent advances in the molecular biology of hepatitis C virus

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