Upregulation of interleukin-12 and -17 in active inflammatory bowel disease.

  title={Upregulation of interleukin-12 and -17 in active inflammatory bowel disease.},
  author={Ole Haagen Nielsen and Irena Kirman and Niels R{\"u}diger and Jakob Hendel and Ben Vainer},
  journal={Scandinavian journal of gastroenterology},
  volume={38 2},
BACKGROUND Cytokines are essential mediators of the intestinal inflammation during active episodes of inflammatory bowel disease (IBD). Interleukin (IL)-12 and IL-17 are potent immunoregulatory cytokines whose roles in the pathogenesis of IBD are unknown. The aim of this study was to evaluate the colonic expression of IL-12 and IL-17 genes in IBD. METHODS Fifty-one patients (22 with ulcerative colitis (UC), 17 with Crohn disease (CD), and 12 controls) who underwent colonoscopy were included… CONTINUE READING
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