Upregulation of inducible nitric oxide synthase and nitric oxide occurs later than the onset of the hyperdynamic response during sepsis.

@article{Shieh2000UpregulationOI,
  title={Upregulation of inducible nitric oxide synthase and nitric oxide occurs later than the onset of the hyperdynamic response during sepsis.},
  author={Pochuen Shieh and Mian Zhou and David A Ornan and Irshad H. Chaudry and Ping Wang},
  journal={Shock},
  year={2000},
  volume={13 4},
  pages={325-9}
}
Polymicrobial sepsis is characterized by an early, hyperdynamic phase (i.e., 2-10 h after cecal ligation and puncture [CLP]) followed by a late, hypodynamic phase (16 h after CLP or later). Although nitric oxide (NO) plays an important role in the pathophysiologic response during sepsis, it remains unknown how early NO is upregulated after the onset of sepsis and which organs are responsible for producing the increased amount of NO. To study this, male rats were subjected to sepsis by CLP… CONTINUE READING