Upregulation of gastric norepinephrine with beta-adrenoceptors and gastric dysmotility in a rat model of functional dyspepsia.

  title={Upregulation of gastric norepinephrine with beta-adrenoceptors and gastric dysmotility in a rat model of functional dyspepsia.},
  author={J. Song and T. Wang and X. Zhang and B. Li and S. Zhang},
  journal={Physiological research},
Disordered motility is one of the most important pathogenic characteristics of functional dyspepsia (FD), although the underlying mechanisms remain unclear. Since the sympathetic system is important to the regulation of gastrointestinal motility, the present study aimed to investigate the role of norepinephrine (NE) and adrenoceptors in disordered gastric motility in a rat model with FD. The effect of exogenous NE on gastric motility in control and FD rats was measured through an organ bath… Expand
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Upregulation of β1-adrenoceptors is involved in the formation of gastric dysmotility in the 6-hydroxydopamine rat model of Parkinson's disease.
  • Jin-Hua Song, L. Zheng, +6 authors J. Zhu
  • Chemistry, Medicine
  • Translational research : the journal of laboratory and clinical medicine
  • 2014
β3-AR involves the regulation of gastric motility in control rats, whereas the upregulation of β1-AR is responsible for enhanced NE reactivity in 6-OHDA rats and therefore is involved in the formation of gastroparesis. Expand
Alteration of enteric monoamines with monoamine receptors and colonic dysmotility in 6-hydroxydopamine-induced Parkinson's disease rats.
  • Xiao-li Zhang, Yun Li, +8 authors J. Zhu
  • Chemistry, Medicine
  • Translational research : the journal of laboratory and clinical medicine
  • 2015
It is concluded that enhanced DA and β3-ARs and decreased 5-HT4 receptors may be contributed to the colonic dysmotility and constipation observed in 6-OHDA rats. Expand
Enhanced sympathetic nerve activity induced by neonatal colon inflammation induces gastric hypersensitivity and anxiety-like behavior in adult rats.
  • J. Winston, S. Sarna
  • Medicine
  • American journal of physiology. Gastrointestinal and liver physiology
  • 2016
It is concluded that neonatal programming triggered by colon inflammation upregulates tyrosine hydroxylase in the celiac ganglia, which upregulate the release of NE in the gastric fundus muscularis externa, which proportionately increases the visceromotor response to gastric distention. Expand
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Alternative molecular mechanisms, including a higher efficiency in the coupling between receptor activation and downstream intracellular effector systems, possibly independent from inhibitory G(i/o) proteins, may be accounted for the development of supersensitivity to DAMGO. Expand
Review article: adrenergic control of motor and secretory function in the gastrointestinal tract
The role that the sympathetic nervous system plays in modulating physiological processes in the gastrointestinal tract is becoming clearer. It is now known that motor, secretomotor and vasomotorExpand
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The sympathetic nervous system plays an important role in regulating basal ion transport in the colorectum and was found to be significantly lower in catecholamine-depleted rats compared to the controls. Expand
Functional interaction between α2-adrenoceptors, μ- and κ-opioid receptors in the guinea pig myenteric plexus: Effect of chronic desipramine treatment
Abstract The existence of a functional interplay between α 2 -adrenoceptor and opioid receptor inhibitory pathways modulating neurotransmitter release has been demonstrated in the enteric nervousExpand
Pre- and postsynaptic mechanisms in the clonidine- and oxymetazoline-induced inhibition of gastric motility in the rat
While clonidine reduces the gastric motility by activation of presynaptic alpha2-adrenoceptors, postsynaptic component in the effect of oxymetazoline has also been raised and suggest that different mechanisms may be involved in the inhibitory effect. Expand
Influences of Norepinephrine Transporter Function on the Distribution of Sympathetic Activity in Humans
It is concluded that norepinephrine reuptake function profoundly influences the distribution of sympathetic activity between the heart, vasculature, and kidney in humans and these changes are physiologically relevant because they lead to corresponding changes in organ function. Expand
Release of catecholamines in the locus coeruleus of freely moving and anaesthetized normotensive and spontaneously hypertensive rats: effects of cardiovascular changes and tail pinch
The findings show that in adult rats, genetic hypertension does not modify the release of noradrenaline and dopamine in the locus coeruleus, and it seems that both amines possess a counteracting, hypertensive function in the rat locus coercedus. Expand