Upregulation of forkhead box O3 transcription is involved in C2-ceramide induced apoptosis and autophagy in ovarian cancer cells in vitro.

@article{Jin2014UpregulationOF,
  title={Upregulation of forkhead box O3 transcription is involved in C2-ceramide induced apoptosis and autophagy in ovarian cancer cells in vitro.},
  author={Zhishan Jin and Lang Zheng and Xiaoyan Xin and Yuanyue Li and Teng Hua and Tingting Wu and Hongbo Wang},
  journal={Molecular medicine reports},
  year={2014},
  volume={10 6},
  pages={3099-105}
}
Ceramide is a bioactive lipid which functions as a tumor suppressor, mediating processes such as apoptosis, growth arrest, senescence and differentiation. The effects of ceramide in ovarian cancers have not been well established. The objective of the present study was to investigate the effects of C2‑ceramide treatment in A2780 ovarian cancer cells and its possible molecular mechanism. C2‑ceramide-induced proliferation inhibition was analyzed using an MTT assay and Trypan blue test. Flow… CONTINUE READING
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