Upregulation of fatty acyl-CoA thioesterases in the heart and skeletal muscle of rats fed a high-fat diet.

@article{Fujita2011UpregulationOF,
  title={Upregulation of fatty acyl-CoA thioesterases in the heart and skeletal muscle of rats fed a high-fat diet.},
  author={Mariko Fujita and Atsushi Momose and Takayuki Ohtomo and Azusa Nishinosono and Kouichi Tanonaka and Hiroo Toyoda and Masako Morikawa and Junji Yamada},
  journal={Biological & pharmaceutical bulletin},
  year={2011},
  volume={34 1},
  pages={87-91}
}
In rodent models of diet-induced obesity, prolonged high-fat feeding increases the cellular uptake of fatty acids and causes lipotoxicity in the heart and skeletal muscle, where substrate overload to beta-oxidation generates mitochondrial stress. We examined the hypothesis that, because of its catalytic properties, acyl-CoA thioesterase (ACOT) would counteract these detrimental situations by modulating intracellular acyl-CoA levels. Rats were fed a low- or high-fat diet for up to 20 weeks, and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Similar Papers

Loading similar papers…