Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors.

@article{Laufs1998UpregulationOE,
  title={Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors.},
  author={Ulrich Laufs and V La Fata and Jorge Plutzky and James K. Liao},
  journal={Circulation},
  year={1998},
  volume={97 12},
  pages={1129-35}
}
BACKGROUND Oxidized low-density lipoprotein (ox-LDL) causes endothelial dysfunction in part by decreasing the availability of endothelial nitric oxide (NO). Although HMG CoA reductase inhibitors restore endothelial function by reducing serum cholesterol levels, it is not known whether they can also directly upregulate endothelial NO synthase (ecNOS) activity. METHODS AND RESULTS Human saphenous vein endothelial cells were treated with ox-LDL (50 microg/mL thiobarbituric acid reactive… CONTINUE READING
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