Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors.

  title={Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors.},
  author={Ulrich Laufs and V La Fata and Jorge Plutzky and James K. Liao},
  volume={97 12},
BACKGROUND Oxidized low-density lipoprotein (ox-LDL) causes endothelial dysfunction in part by decreasing the availability of endothelial nitric oxide (NO). Although HMG CoA reductase inhibitors restore endothelial function by reducing serum cholesterol levels, it is not known whether they can also directly upregulate endothelial NO synthase (ecNOS) activity. METHODS AND RESULTS Human saphenous vein endothelial cells were treated with ox-LDL (50 microg/mL thiobarbituric acid reactive… CONTINUE READING
Highly Influential
This paper has highly influenced 24 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
652 Citations
32 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 652 extracted citations


Publications referenced by this paper.
Showing 1-10 of 32 references

Similar Papers

Loading similar papers…