Upregulation of cortical COX-2 in salt-sensitive hypertension: role of angiotensin II and reactive oxygen species.

@article{Jaimes2008UpregulationOC,
  title={Upregulation of cortical COX-2 in salt-sensitive hypertension: role of angiotensin II and reactive oxygen species.},
  author={Edgar A. Jaimes and Ming-Sheng Zhou and Damien D Pearse and Leopold Puzis and Leopoldo Raij},
  journal={American journal of physiology. Renal physiology},
  year={2008},
  volume={294 2},
  pages={F385-92}
}
Salt-sensitive (SS) hypertension is a vascular diathesis characterized by reduced cardiovascular and renal nitric oxide bioavailability and local upregulation of ANG II. We have demonstrated that rats infused with ANG II manifest increased cortical cyclooxygenase (COX)-2 expression and activity via NADPH oxidase-derived reactive oxygen species (ROS). In the… CONTINUE READING