Upregulation of cellular triacylglycerol - free fatty acid cycling by oleate is associated with long-term serum-free survival of human breast cancer cells.

@article{Przybytkowski2007UpregulationOC,
  title={Upregulation of cellular triacylglycerol - free fatty acid cycling by oleate is associated with long-term serum-free survival of human breast cancer cells.},
  author={Ewa Przybytkowski and Erik Joly and Christopher James Nolan and Serge Hardy and A M Francoeur and Yves Langelier and Marc Prentki},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  year={2007},
  volume={85 3},
  pages={301-10}
}
We previously showed that exogenous oleate protects human breast cancer cells against palmitate-induced apoptosis in part by increasing esterification of this free fatty acid (FFA) into triacylglycerol (TG). Here, we studied the mechanism whereby oleate protects these cells against apoptosis induced by serum withdrawal. The metabolism of FFA, TG, and glucose, in parallel with long-term cell survival in the absence of serum, was investigated in a panel of human breast cancer cell lines and in… CONTINUE READING

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