Upregulation of caveolin in multidrug resistant cancer cells: functional implications.

@article{Lavie2001UpregulationOC,
  title={Upregulation of caveolin in multidrug resistant cancer cells: functional implications.},
  author={Yaakov Lavie and Giusy Fiucci and Mordechai Liscovitch},
  journal={Advanced drug delivery reviews},
  year={2001},
  volume={49 3},
  pages={
          317-23
        }
}
Multidrug resistance (MDR) is a multifactorial process that involves elevated expression of drug transporters as well as additional biochemical changes that contribute to the drug resistant phenotype. Here we review recent results indicating the upregulation of constituents of rafts and caveolae, including glucosylceramide, cholesterol and caveolin-1, in MDR cells. Accordingly, the number of plasma membrane caveolae is greatly increased in MDR cells. The relationship between caveolin and MDR… CONTINUE READING
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