Upregulation of caveolin-1 expression is associated with structural modifications of endothelial cells in diabetic lung.


Diabetes and the associated hyperglycemia affect pulmonary physiology and biochemistry inducing endothelial impairment, as the first step in lung vascular dysfunction. Caveolin-1, a characteristic protein of endothelial caveolae, acts as a scaffolding protein involved in signal transduction, cholesterol homeostasis, and vesicular trafficking. To document… (More)
DOI: 10.1016/j.mvr.2009.11.008