Upregulation of cardiac cell plasma membrane calcium pump in a canine model of Chagas disease.

@article{Barr2003UpregulationOC,
  title={Upregulation of cardiac cell plasma membrane calcium pump in a canine model of Chagas disease.},
  author={Stephen C Barr and Thomas L Pannabecker and Robert F. Gilmour and John S. Chandler},
  journal={The Journal of parasitology},
  year={2003},
  volume={89 2},
  pages={381-4}
}
We have previously demonstrated that cardiac myocytes isolated from the hearts of adult dogs develop rapid repetitive cytosolic Ca2+ transients, membrane depolarization, and cell contraction by mobilization of sarcoplasmic reticulum Ca2+ stores when exposed to a soluble factor from the trypomastigotes of Trypanosoma cruzi. These findings led us to investigate the regulatory mechanisms of cytosolic Ca2+ in cardiac tissues from dogs chronically infected with T. cruzi. Expression of the plasma… CONTINUE READING