Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer’s disease brain

@article{Kurbatskaya2016UpregulationOC,
  title={Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer’s disease brain},
  author={Ksenia Kurbatskaya and Emma Claire Phillips and Cara L Croft and Giacomo Dentoni and Martina M. Hughes and Matthew A. Wade and Safa Al-Sarraj and Claire Troakes and Michael J. O'Neill and Beatriz G. P{\'e}rez-Nievas and Diane P Hanger and Wendy Noble},
  journal={Acta Neuropathologica Communications},
  year={2016},
  volume={4},
  pages={1-15}
}
Alterations in calcium homeostasis are widely reported to contribute to synaptic degeneration and neuronal loss in Alzheimer’s disease. Elevated cytosolic calcium concentrations lead to activation of the calcium-sensitive cysteine protease, calpain, which has a number of substrates known to be abnormally regulated in disease. Analysis of human brain has shown that calpain activity is elevated in AD compared to controls, and that calpain-mediated proteolysis regulates the activity of important… CONTINUE READING
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