Upregulation of c-myc gene accompanied by PU.1 deficiency in radiation-induced acute myeloid leukemia in mice.

@article{Hirouchi2008UpregulationOC,
  title={Upregulation of c-myc gene accompanied by PU.1 deficiency in radiation-induced acute myeloid leukemia in mice.},
  author={Tokuhisa Hirouchi and Takashi Takabatake and Kazuko Yoshida and Yumiko Nitta and Masako Nakamura and Satoshi Tanaka and Kazuaki Ichinohe and Yoichi Oghiso and Kimio Tanaka},
  journal={Experimental hematology},
  year={2008},
  volume={36 7},
  pages={871-85}
}
OBJECTIVE High-dose radiation exposure induces acute myeloid leukemia (AML) in C3H mice, most of which have a frequent hemizygous deletion around the D2Mit15 marker on chromosome 2. This region includes PU.1, a critical candidate gene for initiation of leukemogenesis. To identify novel cooperative genes with PU.1, relevant to radiation-induced leukemogenesis, we analyzed the copy number alterations of tumor-related gene loci by array CGH, and their expressions in primary and transplanted AMLs… CONTINUE READING
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