Upregulation of c-Fos in activated T lymphoid and monocytic cells by human immunodeficiency virus-1 Tat protein.

@article{Gibellini1997UpregulationOC,
  title={Upregulation of c-Fos in activated T lymphoid and monocytic cells by human immunodeficiency virus-1 Tat protein.},
  author={Davide Gibellini and Antonella Caputo and Silvano Capitani and Michele La Placa and Giorgio Zauli},
  journal={Blood},
  year={1997},
  volume={89 5},
  pages={1654-64}
}
The regulatory Tat protein of the human immunodeficiency virus type-1 (HIV-1) is essential for viral replication and also shows pleiotropic activities on various cell functions. To get further insights into the molecular mechanisms underlying the biological activity of Tat, we investigated the effect of endogenous and exogenous Tat protein on c-fos gene expression in T lymphoblastoid (Jurkat) and monocytic (U937) cell lines, as well as in primary peripheral blood mononuclear cells (PBMC… CONTINUE READING

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