Upregulation of beta(3)-adrenoceptors and altered contractile response to inotropic amines in human failing myocardium.

@article{Moniotte2001UpregulationOB,
  title={Upregulation of beta(3)-adrenoceptors and altered contractile response to inotropic amines in human failing myocardium.},
  author={St{\'e}phane Moniotte and Lester Kobzik and Olivier F{\'e}ron and Jean No{\"e}l Trochu and Cindy Gauthier and Jean-Luc Balligand},
  journal={Circulation},
  year={2001},
  volume={103 12},
  pages={1649-55}
}
BACKGROUND Contrary to beta(1)- and beta(2)-adrenoceptors, beta(3)-adrenoceptors mediate a negative inotropic effect in human ventricular muscle. To assess their functional role in heart failure, our purpose was to compare the expression and contractile effect of beta(3)-adrenoceptors in nonfailing and failing human hearts. METHODS AND RESULTS We analyzed left ventricular samples from 29 failing (16 ischemic and 13 dilated cardiomyopathic) hearts (ejection fraction 18.6+/-2%) and 25… CONTINUE READING

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