Upregulation of basal TGFbeta1 levels by EMF coincident with chondrogenesis--implications for skeletal repair and tissue engineering.

@article{Aaron2002UpregulationOB,
  title={Upregulation of basal TGFbeta1 levels by EMF coincident with chondrogenesis--implications for skeletal repair and tissue engineering.},
  author={Roy K. Aaron and Shuo Wang and Deborah McK Ciombor},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2002},
  volume={20 2},
  pages={233-40}
}
Members of the TGFbeta/BMP gene family regulate cartilage and bone development. These genes are re-expressed in bone repair and are thought to mediate chondro- and osteoprogenitor cell differentiation. These observations have led to a therapeutic strategy of introducing these growth factors into experimental cartilage and bone defects. Therapeutic efficacy, however, has been limited by diffusion or inactivation of these growth factors from the desired site and by the inability to deliver… CONTINUE READING

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