Upregulation of arginase-II contributes to decreased age-related myocardial contractile reserve

Abstract

Arginase-II (Arg-II) reciprocally regulates nitric oxide synthase (NOS) and offsets basal myocardial contractility. Furthermore, decreased or absent myocardial NOS activity is associated with a depression in myocardial contractile reserve. We therefore hypothesized that upregulation of Arg-II might in part be responsible for depressed myocardial… (More)
DOI: 10.1007/s00421-011-2257-9

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