Upregulation of angiotensin-converting enzyme by vascular endothelial growth factor.

@article{Saijonmaa2001UpregulationOA,
  title={Upregulation of angiotensin-converting enzyme by vascular endothelial growth factor.},
  author={Outi J Saijonmaa and Tuulikki Nyman and Risto Kosonen and Frej Y Fyhrquist},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2001},
  volume={280 2},
  pages={
          H885-91
        }
}
The role of vascular endothelial growth factor (VEGF), a potent endothelium-specific angiogenic factor, in the regulation of angiotensin-converting enzyme (ACE) in cultured human umbilical vein endothelial cells (HUVECs) was studied. VEGF (0.07-1.2 x 10(-6) mmol/l) caused a dose-dependent increase in ACE measured in intact endothelial cells and increased the expression of ACE mRNA. The stimulatory effect of VEGF was inhibited by pretreatment of endothelial cells with the tyrosine kinase… CONTINUE READING

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  • 2005
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