Upregulation of angiotensin-converting enzyme 2 by all-trans retinoic acid in spontaneously hypertensive rats.

@article{Zhong2004UpregulationOA,
  title={Upregulation of angiotensin-converting enzyme 2 by all-trans retinoic acid in spontaneously hypertensive rats.},
  author={J Zhong and Dong-yang Huang and Y Yang and Yifan David Li and Ge-fei Liu and X Song and Kun Du},
  journal={Hypertension},
  year={2004},
  volume={44 6},
  pages={907-12}
}
There is increasing evidence that all-trans retinoic acid (atRA) influences gene expression of components of renin-angiotensin system (RAS), which plays a pivotal role in the pathophysiology of essential hypertension. To further validate effects of atRA on the RAS and to assess the possibility that atRA affects the activity of angiotensin-converting enzyme 2 (ACE2), gene, and protein expression of ACE2 have been examined by real-time polymerase chain reaction and Western blot methods in… CONTINUE READING
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