Upregulation of angiotensin-converting enzyme (ACE) 2 in hepatic fibrosis by ACE inhibitors.

  title={Upregulation of angiotensin-converting enzyme (ACE) 2 in hepatic fibrosis by ACE inhibitors.},
  author={Mao-liang Huang and Xin Li and Ying Meng and Bing Xiao and Qiang Ma and Song-song Ying and Ping-sheng Wu and Zhen-shu Zhang},
  journal={Clinical and experimental pharmacology & physiology},
  volume={37 1},
1. The role of angiotensin-converting enzyme (ACE) 2 is likely to balance the status of the renin-angiotensin system (RAS) by degrading angiotensin (Ang) II and generating Ang-(1-7). Earlier demonstrations that ACE2 is insensitive to ACE inhibitors prompted us to evaluate the effect of ACE inhibitors on ACE2 expression. 2. Liver fibrosis was induced in rats with 40% CCl(4) (2.5 mL/kg, s.c., twice per week). Half the rats were further treated with perindopril (2 mg/kg, p.o., daily). After 2 and… CONTINUE READING


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Differential regulation of renal angiotensin-converting enzyme (ACE) and ACE2 during ACE inhibition and dietary sodium restriction in healthy rats

  • I Hamming, H van Goor, AJ Turner
  • Exp. Physiol
  • 2008
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