Upregulation of alpha cell glucagon-like peptide 1 (GLP-1) in Psammomys obesus—an adaptive response to hyperglycaemia?

  title={Upregulation of alpha cell glucagon-like peptide 1 (GLP-1) in Psammomys obesus—an adaptive response to hyperglycaemia?},
  author={Ann Maria Kruse Hansen and Th{\'o}ra B. B{\"o}dvarsdottir and D. N. E. Nordestgaard and Robert S Heller and Carsten F. Gotfredsen and Kathrin Maedler and Johannes Josef Fels and Jens Juul Holst and Allan Ertman Karlsen},
The hormone glucagon-like peptide 1 (GLP-1) is released in response to a meal from the intestinal L-cells, where it is processed from proglucagon by the proconvertase (PC)1/3. In contrast, in the adult islets proglucagon is processed to glucagon by the PC2 enzyme. The aim of the study was to evaluate if, during the development of diabetes, alpha cells produce GLP-1 that, in turn, might trigger beta cell growth. Beta cell mass, GLP-1 and insulin levels were measured in the gerbil Psammomys… CONTINUE READING


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