Upregulation of aldolase B and overproduction of methylglyoxal in vascular tissues from rats with metabolic syndrome.

@article{Liu2011UpregulationOA,
  title={Upregulation of aldolase B and overproduction of methylglyoxal in vascular tissues from rats with metabolic syndrome.},
  author={Jianghai Liu and Rui Wang and Kaushik Desai and Ling-Yun Wu},
  journal={Cardiovascular research},
  year={2011},
  volume={92 3},
  pages={494-503}
}
AIMS Methylglyoxal (MG) overproduction has been reported in metabolic syndrome with hyperglycaemia (diabetes) or without hyperglycaemia (hypertension), and the underlying mechanism was investigated. METHODS AND RESULTS Contributions of different pathways or enzymes to MG formation were evaluated in aorta or cultured vascular smooth muscle cells (VSMCs). In all four animal models of metabolic syndrome, i.e. chronically fructose-fed hypertensive Sprague-Dawley rats, spontaneously hypertensive… CONTINUE READING
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