Upregulation of adiponectin receptor 1 and 2 mRNA and protein in adipose tissue and adipocytes in insulin-resistant women with polycystic ovary syndrome

@article{Tan2006UpregulationOA,
  title={Upregulation of adiponectin receptor 1 and 2 mRNA and protein in adipose tissue and adipocytes in insulin-resistant women with polycystic ovary syndrome},
  author={Bee Kang Tan and Jinfeng Chen and Janet E. Digby and Stephen D. Keay and Christopher R. J. Kennedy and Harpal Randeva},
  journal={Diabetologia},
  year={2006},
  volume={49},
  pages={2723-2728}
}
Polycystic ovary syndrome (PCOS) is a multifaceted metabolic disease linked with insulin resistance (IR) and obesity. Adiponectin, which is lower in IR states, exerts its glucose-lowering and anti-inflammatory effects by activating two receptors, ADIPOR1 and ADIPOR2. There are no data on the relative expression of these receptors in adipose tissue of PCOS women. We investigated the expression of adiponectin receptors from corresponding s.c. and omental (o.m.) adipose tissue in women with PCOS… CONTINUE READING