Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents.

@article{Boyer2006UpregulationOA,
  title={Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents.},
  author={James L. Boyer and Michael A. Trauner and Albert Mennone and Carol J. Soroka and Shi-Ying Cai and Tarek Mohamed Mohamed Moustafa and Gernot Zollner and Jin Young Lee and Nazzareno Ballatori},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2006},
  volume={290 6},
  pages={
          G1124-30
        }
}
Organic solute transporter (OSTalpha-OSTbeta) is a novel heteromeric bile acid and sterol transporter expressed at the basolateral membranes of epithelium in the ileum, kidney, and liver. To determine whether OSTalpha-OSTbeta undergoes farnesoid X receptor (FXR)-dependent adaptive regulation following cholestatic liver injury, mRNA and protein expression levels were analyzed in patients with primary biliary cirrhosis (PBC) and following common bile duct ligation (CBDL) in rats and Fxr null and… CONTINUE READING

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