Upregulation of VEGF-C by androgen depletion: the involvement of IGF-IR-FOXO pathway

@article{Li2005UpregulationOV,
  title={Upregulation of VEGF-C by androgen depletion: the involvement of IGF-IR-FOXO pathway},
  author={Jinping Li and Enfeng Wang and Francesca Rinaldo and Kaustubh Datta},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={5510-5520}
}
Androgen ablation therapy is eventually followed by a more metastatic and androgen-refractory stage of prostate cancer. The detailed molecular mechanism of this gradual transition is not clearly understood. Recent reports correlate the high abundance of vascular endothelial growth factor-C (VEGF-C) to the lymph node metastasis seen in human prostate cancer (Tsurusaki et al., 1999). In this study, we report that androgen ablation in LNCaP cells augment the transcriptional upregulation of VEGF-C… CONTINUE READING
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