Upregulation of Twist-1 by NF-kappaB blocks cytotoxicity induced by chemotherapeutic drugs.

@article{Pham2007UpregulationOT,
  title={Upregulation of Twist-1 by NF-kappaB blocks cytotoxicity induced by chemotherapeutic drugs.},
  author={Can G. Pham and Concetta Bubici and Francesca Zazzeroni and James R Knabb and Salvatore Papa and Christian Kuntzen and Guido Franzoso},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 11},
  pages={3920-35}
}
NF-kappaB/Rel transcription factors are central to controlling programmed cell death (PCD). Activation of NF-kappaB blocks PCD induced by numerous triggers, including ligand engagement of tumor necrosis factor receptor (TNF-R) family receptors. The protective activity of NF-kappaB is also crucial for oncogenesis and cancer chemoresistance. Downstream of TNF-Rs, this activity of NF-kappaB has been linked to the suppression of reactive oxygen species and the c-Jun-N-terminal-kinase (JNK) cascade… CONTINUE READING

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