Upregulation of TRPM7 channels by angiotensin II triggers phenotypic switching of vascular smooth muscle cells of ascending aorta.

@article{Zhang2012UpregulationOT,
  title={Upregulation of TRPM7 channels by angiotensin II triggers phenotypic switching of vascular smooth muscle cells of ascending aorta.},
  author={Zheng Zhang and Mi Wang and Xiao-han Fan and Jing-hui Chen and Yong-Yuan Guan and Yong-Bo Tang},
  journal={Circulation research},
  year={2012},
  volume={111 9},
  pages={1137-46}
}
RATIONALE Angiotensin II (Ang II) has pleiotropic effects on vascular smooth muscle cells (VSMCs). It has been demonstrated to promote the proliferative phenotype of VSMCs in mouse ascending aorta, but the underlying mechanisms remain incompletely understood. OBJECTIVE The present study was designed to explore whether the Ca(2+)-permeable transient receptor potential melastatin 7 (TRPM7) channel is involved in Ang II-induced phenotype switching of ascending aortic VSMCs and to dissect the… CONTINUE READING

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