Upregulation of TRPC1/6 may be involved in arterial remodeling in rat.

  title={Upregulation of TRPC1/6 may be involved in arterial remodeling in rat.},
  author={Xiao-hong Lin and Hua-shan Hong and Guang-Rong Zou and Liang-long Chen},
  journal={The Journal of surgical research},
  volume={195 1},
BACKGROUND Hypertension and its complications are associated with arterial remodeling. Transient receptor potential cationic channels (TRPCs) are important nonselective cationic channels that regulate calcium homeostasis in mammalian cell membranes. We aimed to study the expression of various TRPC isoforms in spontaneously hypertensive rat (SHR) carotid arterial remodeling and explore the relationship between SHR carotid arterial remodeling and TRPC expression. MATERIALS AND METHODS Thirty… CONTINUE READING
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