Upregulation of TRAF-3 by shear stress blocks CD40-mediated endothelial activation.

@article{Urbich2001UpregulationOT,
  title={Upregulation of TRAF-3 by shear stress blocks CD40-mediated endothelial activation.},
  author={Carmen Urbich and Ziad Mallat and Alain Tedgui and Matthias Clauss and Andreas Michael Zeiher and Stefanie Dimmeler},
  journal={The Journal of clinical investigation},
  year={2001},
  volume={108 10},
  pages={1451-8}
}
Atherosclerosis is an inflammatory disease of large arteries that is initiated through the activation of endothelium by proinflammatory mediators. CD40 receptor stimulation has been implicated in the pathogenesis of atherosclerosis. One of the most important atheroprotective stimuli is the viscous drag (shear stress) generated by the streaming blood acting on the endothelial monolayer. Here, we demonstrate that shear stress prevents CD40 ligand-induced endothelial cell activation, and we… CONTINUE READING