Upregulation of TGF-ß1 in experimental proliferative vitreoretinopathy is accompanied by epithelial to mesenchymal transition

@article{Hoerster2013UpregulationOT,
  title={Upregulation of TGF-\ss1 in experimental proliferative vitreoretinopathy is accompanied by epithelial to mesenchymal transition},
  author={Robert Hoerster and Philipp Sebastian Muether and Sarah Vierkotten and Manuel Marcel Hermann and Bernd Kirchhof and Sascha Fauser},
  journal={Graefe's Archive for Clinical and Experimental Ophthalmology},
  year={2013},
  volume={252},
  pages={11-16}
}
Proliferative vitreoretinopathy (PVR) is characterized by epithelial to mesenchymal transition (EMT) of retinal pigment epithelium (RPE) cells and consecutive formation of fibrous membranes, leading to retinal redetachment. Transforming growth factor beta (TGF-ß) has been suggested to play an important role in this process, but the role of TGF-ß isoforms is unknown. In pigmented rabbits (n = 14), PVR was induced by cryopexy and a full-thickness limbus-parallel incision. PVR was evaluated by… CONTINUE READING