Upregulation of TCF4 expression as a transcriptional target of β-catenin/p300 complexes during trans-differentiation of endometrial carcinoma cells

@article{Saegusa2005UpregulationOT,
  title={Upregulation of TCF4 expression as a transcriptional target of β-catenin/p300 complexes during trans-differentiation of endometrial carcinoma cells},
  author={Makoto Saegusa and Miki Hashimura and Takeshi Kuwata and Mieko Hamano and Isao Okayasu},
  journal={Laboratory Investigation},
  year={2005},
  volume={85},
  pages={768-779}
}
Nuclear stabilization of β-catenin and its interaction with TCF/LEF factors are key events in transduction of the Wnt/β-catenin signal pathway. Our previous study indicated that nuclear β-catenin accumulation provides an initial signal for trans-differentiation toward the squamoid phenotype of endometrial carcinoma (Em Ca) cells in a TCF4-dependent manner, which makes this a possible factor for a positive prognosis. However, little is known about regulation of TCF4 expression in Em Cas. We show… CONTINUE READING