Upregulation of Src homology phosphotyrosyl phosphatase 2 (Shp2) expression in oral cancer and knockdown of Shp2 expression inhibit tumor cell viability and invasion in vitro.

@article{Xie2014UpregulationOS,
  title={Upregulation of Src homology phosphotyrosyl phosphatase 2 (Shp2) expression in oral cancer and knockdown of Shp2 expression inhibit tumor cell viability and invasion in vitro.},
  author={Hongjun Xie and Shengyun Huang and Wengang Li and Hongbo Zhao and Tianqi Zhang and Dongsheng Zhang},
  journal={Oral surgery, oral medicine, oral pathology and oral radiology},
  year={2014},
  volume={117 2},
  pages={234-42}
}
OBJECTIVE This study investigated the clinical significance of Shp2 protein expression in oral squamous cell carcinoma (OSCC) and elucidated its biologic significance in OSCC cells. STUDY DESIGN A total of 88 OSCC cases were used to assess Shp2 expression, out of which 70 were for immunohistochemistry and 18 paired tumors vs normal tissues were for Western blot of Shp2 expression. OSCC cells were used to assess the effects of Shp2 knockdown for cell viability, apoptosis, invasion, and protein… CONTINUE READING