Upregulation of P2RX7 in Cx3cr1-Deficient Mononuclear Phagocytes Leads to Increased Interleukin-1β Secretion and Photoreceptor Neurodegeneration.

@article{Hu2015UpregulationOP,
  title={Upregulation of P2RX7 in Cx3cr1-Deficient Mononuclear Phagocytes Leads to Increased Interleukin-1β Secretion and Photoreceptor Neurodegeneration.},
  author={Shulong Justin Hu and Bertrand Calippe and Sophie Lavalette and Christophe Roubeix and Fadoua Montassar and Michael Housset and Olivier Levy and C{\'e}cile Delarasse and Michel P{\^a}ques and Jos{\'e}-Alain Sahel and Florian Sennlaub and Xavier Guillonneau},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2015},
  volume={35 18},
  pages={
          6987-96
        }
}
Photoreceptor degeneration in age-related macular degeneration (AMD) is associated with an infiltration and chronic accumulation of mononuclear phagocytes (MPs). We have previously shown that Cx3cr1-deficient mice develop age- and stress- related subretinal accumulation of MPs, which is associated with photoreceptor degeneration. Cx3cr1-deficient MPs have been shown to increase neuronal apoptosis through IL-1β in neuroinflammation of the brain. The reason for increased IL-1β secretion from… CONTINUE READING
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