Upregulation of Nox4 by TGF{beta}1 oxidizes SERCA and inhibits NO in arterial smooth muscle of the prediabetic Zucker rat.

@article{Tong2010UpregulationON,
  title={Upregulation of Nox4 by TGF\{beta\}1 oxidizes SERCA and inhibits NO in arterial smooth muscle of the prediabetic Zucker rat.},
  author={Xiaoyong Tong and Xiuyun Hou and David Jourd'heuil and Robert M. Weisbrod and Richard Alan Cohen},
  journal={Circulation research},
  year={2010},
  volume={107 8},
  pages={
          975-83
        }
}
RATIONALE Vascular smooth muscle cell (SMC) migration is an important pathological process in several vascular occlusive diseases, including atherosclerosis and restenosis, both of which are accelerated by diabetes mellitus. OBJECTIVE To determine the mechanisms of abnormal vascular SMC migration in type 2 diabetes, the obese Zucker rat (ZO), a model of obesity and insulin resistance, was studied. METHODS AND RESULTS In culture, ZO aortic SMCs showed a significant increase in Nox4 mRNA and… CONTINUE READING
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