Upregulation of Neuronal Nitric Oxide Synthase in in Vitro Stellate Astrocytes and in Vivo Reactive Astrocytes After Electrically Induced Status Epilepticus

@article{Catania2003UpregulationON,
  title={Upregulation of Neuronal Nitric Oxide Synthase in in Vitro Stellate Astrocytes and in Vivo Reactive Astrocytes After Electrically Induced Status Epilepticus},
  author={M V Catania and Raffaella Giuffrida and Giovanna Seminara and Giuseppe Maria Barbagallo and E. Aronica and Jan A. Gorter and Paola Dell'Albani and Agrippino Ravagna and Vittorio Calabrese and Anna Maria Giuffrida-Stella},
  journal={Neurochemical Research},
  year={2003},
  volume={28},
  pages={607-615}
}
Neuronal nitric oxide synthase (nNOS) is a constitutively expressed and calcium-dependent enzyme. Despite predominantly expressed in neurons, nNOS has been also found in astrocytes, although at lower expression levels. We have studied the regulation of nNOS expression in cultured rat astrocytes from cortex and spinal cord by Western blotting and immunocytochemistry. nNOS was not detectable in cultured astrocytes grown in serum-containing medium (SCM), but was highly expressed after serum… CONTINUE READING
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