Upregulation of Mer receptor tyrosine kinase signaling attenuated lipopolysaccharide-induced lung inflammation.

@article{Choi2013UpregulationOM,
  title={Upregulation of Mer receptor tyrosine kinase signaling attenuated lipopolysaccharide-induced lung inflammation.},
  author={Ji-Yeon Choi and H S Park and Ye-ji Lee and Jiyeon Byun and Young-So Youn and Ji Ha Choi and So-Youn Woo and Jihee Lee Kang},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2013},
  volume={344 2},
  pages={447-58}
}
Mer receptor tyrosine kinase (Mer) signaling plays a central role in the intrinsic inhibition of the inflammatory response to Toll-like receptor activation. Previously, we found that lung Mer protein expression decreased after lipopolysaccharide (LPS) treatment due to enhanced Mer cleavage. The purpose of the present study was to examine whether pharmacologically restored membrane-bound Mer expression upregulates the Mer signaling pathways and suppresses lung inflammatory responses… CONTINUE READING