Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma

@article{Fukuma2003UpregulationOI,
  title={Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma},
  author={Mariko Fukuma and Hajime Okita and Jun-ichi Hata and Akihiro Umezawa},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={1-9}
}
The chromosomal translocation specifically linked to the Ewing sarcoma family results in the generation of fusion proteins comprising the amino terminal portion of EWS and the DNA-binding domain of ets transcription factors. The EWS/ets chimeric proteins act as aberrant transcription factors leading to tumorigenic processes. We searched for genes specifically activated in Ewing sarcoma cells but not in other tumor cell lines using the gene array technique, and found significantly enhanced… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 45 extracted citations

References

Publications referenced by this paper.
Showing 1-9 of 9 references

Jpn

F Urano, A Umezawa, +4 authors J. Hata
J. Cancer Res., 89, 703–711. • 1998
View 11 Excerpts
Highly Influenced

Biochem

F Urano, A Umezawa, W Hong, H Kikuchi, J. Hata
Biophy. Res. Commun., 219, 608–612. • 1996
View 10 Excerpts
Highly Influenced

Br

Y Matsumoto, K Tanaka, +3 authors Y Iwamoto
J. Cancer, 84, 768–775. • 2001
View 2 Excerpts

J

JA Toretsky, T Kalebic, V Blakesley, D LeRoith, LJ. Helman
Biol. Chem., 272, 30 822–30 827. • 1997

Mol

R Pankov, N Neznanov, A Umezawa, RG. Oshima
Cell Biol., 14, 7744–7757. • 1994

Nat

PH Sorensen, SL Lessnick, +3 authors CT. Denny
Genet., 6, 146–151. • 1994

AIDS Res

A Seth, DR Hodge, +4 authors TS. Papas
Hum. Retroviruses, 9, 1017–1023. • 1993
View 3 Excerpts

Lab

R Noguera, TJ Triche, S Navarro, M Tsokos, BA. Llombart
Invest., 66, 143–151. • 1992
View 2 Excerpts

Proc

Thomas PS.
Natl. Acad. Sci. USA, 77, 5201– 5205. • 1980

Similar Papers

Loading similar papers…