Upregulation of ICAM-1 on cardiomyocytes in jeopardized human myocardium during infarction.

@article{Niessen1999UpregulationOI,
  title={Upregulation of ICAM-1 on cardiomyocytes in jeopardized human myocardium during infarction.},
  author={Hans W. M. Niessen and Wim K. Lagrand and Cees A. Visser and Ch J L M Meijer and C. Erik Hack},
  journal={Cardiovascular research},
  year={1999},
  volume={41 3},
  pages={603-10}
}
OBJECTIVE Impaired perfusion of the myocardium induces a local inflammatory response. In animal models, there is ample evidence that polymorphonuclear leucocytes (PMNs) infiltrating infarcted myocardium contribute significantly to infarct size. METHODS To explore a possible role for PMNs in the tissue damage of human myocardial infarction, we investigated localization of intercellular adhesion molecule-1 (ICAM-1) and CD66b (previously clustered as CD67), a marker of degranulation of human… CONTINUE READING