Upregulation of Egr-1 biosynthesis in pituitary gonadotropes following activation of GnRH and muscarinic acetylcholine receptors

Abstract

Stimulation of pituitary gonadotropes expressing the Gq/ 11-coupled gonadotropin releasing hormone (GnRH) and muscarinic M3 acetylcholine receptors with GnRH or carbachol upregulates the biosynthesis of the zinc finger transcription factor Egr-1. Receptor stimulation activates phospholipase C, leading to elevated cytosolic Ca2+ levels following stimulation… (More)
DOI: 10.1186/1471-2202-8-S1-P25

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