Upregulation of D2-class signaling in dopamine-denervated striatum is in part mediated by D3 receptors acting on Ca V 2.1 channels via PIP2 depletion.

@article{Prieto2011UpregulationOD,
  title={Upregulation of D2-class signaling in dopamine-denervated striatum is in part mediated by D3 receptors acting on Ca V 2.1 channels via PIP2 depletion.},
  author={Germ{\'a}n A Prieto and Azucena P{\'e}rez-Burgos and Marcela Palomero-Rivero and Elvira Galarraga and Ren{\'e} Drucker-Col{\'i}n and Jos{\'e} Bargas},
  journal={Journal of neurophysiology},
  year={2011},
  volume={105 5},
  pages={2260-74}
}
The loss of dopaminergic neurons in the substantia nigra compacta followed by striatal dopamine depletion is a hallmark of Parkinson's disease. After dopamine depletion, dopaminergic D(2) receptor (D(2)R)-class supersensitivity develops in striatal neurons. The supersensitivity results in an enhanced modulation of Ca(2+) currents by D(2)R-class receptors. However, the relative contribution of D(2)R, D(3)R, and D(4)R types to the supersensitivity, as well as the mechanisms involved, have not… CONTINUE READING
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