Upregulation of CDK7 in gastric cancer cell promotes tumor cell proliferation and predicts poor prognosis.

Abstract

CDK7 has been known as a component of CDK activating kinase (CAK) complex, the complex was composed of CDK7, Cyclin H and RING finger protein Mat1 that contribute to cell cycle progression by phosphorylating other CDKs. In addition, the complex is also an essential component of general transcription factor TFIIH which controls transcription via activating… (More)
DOI: 10.1016/j.yexmp.2016.05.001

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