Upregulation of CD40 and CD40 ligand (CD154) in patients with moderate hypercholesterolemia.

@article{Garlichs2001UpregulationOC,
  title={Upregulation of CD40 and CD40 ligand (CD154) in patients with moderate hypercholesterolemia.},
  author={Christoph D. Garlichs and Stefan John and Alexander Schmeisser and Saeed Eskafi and Christian Stumpf and Michael Karl and Margarete Goppelt-Struebe and Roland Schmieder and Werner Guenther Daniel},
  journal={Circulation},
  year={2001},
  volume={104 20},
  pages={2395-400}
}
BACKGROUND Hypercholesterolemia, a risk factor for cardiovascular disease, is associated with inflammation and hypercoagulability. Both can be mediated by the CD40 system. This study investigated whether the CD40 system is upregulated in patients with moderate hypercholesterolemia and whether it is influenced by therapy with a hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. METHODS AND RESULTS Fifteen patients with moderate hypercholesterolemia and 15 healthy control subjects… CONTINUE READING

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