Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice.

@article{Sarafova2009UpregulationOC,
  title={Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice.},
  author={Sophia D. Sarafova and François van Laethem and Stanley Adoro and Terry I. Guinter and Susan O. Sharrow and L. Feigenbaum and Alfred Singer},
  journal={Immunity},
  year={2009},
  volume={31 3},
  pages={480-90}
}
The lineage fate of developing thymocytes is determined by the persistence or cessation of T cell receptor (TCR) signaling during positive selection, with persistent TCR signaling required for CD4 lineage choice. We show here that transcriptional upregulation of CD4 expression is essential for error-free lineage choice during major histocompatibility complex class II (MHC II)-specific positive selection and is critical for error-free lineage choice in TCR-transgenic mice whose thymocytes… CONTINUE READING
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