Upregulation of CB1 receptors and agonist-stimulated [35S]GTPγS binding in the prefrontal cortex of depressed suicide victims

@article{Hungund2004UpregulationOC,
  title={Upregulation of CB1 receptors and agonist-stimulated [35S]GTPγS binding in the prefrontal cortex of depressed suicide victims},
  author={Basalingappa L. Hungund and K. Yaragudri Vinod and Suham A. Kassir and Balapal S Basavarajappa and Ratnakumar Yalamanchili and Thomas B. Cooper and J. John Mann and Victoria Arango},
  journal={Molecular Psychiatry},
  year={2004},
  volume={9},
  pages={184-190}
}
Endogenous and exogenous cannabinoids (CBs) acting through the CB1 receptors have been implicated in the regulation of several behavioral and neuroendocrine functions. Modulation of endocannabinoidergic system by ethanol in mouse brain, and the association of suicide and mood disorders with alcoholism suggest possible involvement of the cannabinoidergic system in the pathophysiology of depression and suicide. Therefore, the present study was undertaken to examine the levels of CB1 receptors and… CONTINUE READING

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