Upregulation of Bag-1 by ex vivo gene transfer protects rat livers from ischemia/reperfusion injury.

Abstract

Bag-1 exerts powerful antiapoptotic effects by binding and stabilizing Bcl-2 and interacting with the tumor necrosis factor receptor type I-induced death signal. We examined the effects of overexpression of Bag-1 by ex vivo adenoviral gene transfer on cold (4 degrees C for 24 hr) ischemia/reperfusion (I/R) injury of rat livers. Treatment with adenoviral Bag… (More)

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