Upregulation of Acetylcholinesterase Mediated by p53 Contributes to Cisplatin-Induced Apoptosis in Human Breast Cancer Cell

@inproceedings{Ye2015UpregulationOA,
  title={Upregulation of Acetylcholinesterase Mediated by p53 Contributes to Cisplatin-Induced Apoptosis in Human Breast Cancer Cell},
  author={Xiaolei Ye and Changsong Zhang and Yichen Chen and Tianbao Zhou},
  booktitle={Journal of Cancer},
  year={2015}
}
BACKGROUND The expression of acetylcholinesterase (AChE) could be induced during apoptosis in various cell types. And reduced AChE expression either by siRNA could prevent apoptosis. However, the detailed mechanisms underlying the AChE regulation are largely unknown in human breast cancer cell. MATERIAL AND METHODS MCF-7 cells were cultured and treated by cisplatin in the absence or presence of p53 siRNA. RESULTS In this study, the regulation of AChE expression during apoptosis induced by… CONTINUE READING
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